Is Type 2 Diabetes an Autoimmune Disease? Examining the Link and Potential Treatment Approaches


Diabetes is a prevalent health condition in the US, with around 34 million adults estimated to have the disease. Of these, the vast majority have type 2 diabetes. This form of diabetes develops when the body becomes resistant to insulin, the hormone that regulates blood sugar. While a range of factors can contribute to its development, studies have begun to suggest that there could be an autoimmune link to the disease.

This article will provide an overview of the current scientific findings related to type 2 diabetes and autoimmunity. It will also examine potential treatment approaches and lifestyle changes that could help manage the autoimmune aspect of the disease.

Type 2 Diabetes and Autoimmunity: What’s the Connection?

Autoimmune diseases are health conditions in which the body’s immune system attacks its own cells. This can lead to damage and inflammation in various organs and tissues. Some examples of autoimmune diseases include rheumatoid arthritis and lupus.

Type 2 diabetes is not generally thought of as an autoimmune disease. Instead, it has been typically classified as a metabolic disorder. However, researchers have begun to explore potential connections between type 2 diabetes and autoimmune diseases.

One study published in 2017 found that autoantibodies, a type of antibody that attacks the body’s own organs or tissues, were present in around 60% of people with type 2 diabetes. The study also found that these autoantibodies were more common in people who had developed insulin resistance at a younger age.

The Science Behind Type 2 Diabetes as an Autoimmune Disease

While a range of studies have suggested a link between type 2 diabetes and autoimmune diseases, the scientific community remains somewhat divided on whether type 2 diabetes can be classified as an autoimmune disease itself.

One explanation for the potential autoimmune component of type 2 diabetes is called the “Accelerator Hypothesis.” This theory suggests that chronic inflammation, often present in obesity and type 2 diabetes, can stimulate the immune system to attack the cells that produce insulin. This ultimately leads to insulin resistance and further inflammation, perpetuating a vicious cycle.

Further studies have also identified specific immune system cells and proteins that may be involved in the development of type 2 diabetes. These include T cells, B cells, and various cytokines.

Treating Type 2 Diabetes with Autoimmune Approaches

Currently, the most common approach to treating type 2 diabetes is through lifestyle changes and medication. However, as research into the autoimmune aspects of the disease continues, there is potential for a range of new treatment approaches.

One potential treatment approach could be to use existing autoimmune therapies, such as immunosuppressants, to modulate the immune response that contributes to the development of type 2 diabetes. These therapies could be used in combination with traditional treatments like medication and lifestyle changes to achieve better outcomes for people with the disease.

Another potential approach could be to develop new therapies specifically targeting the autoimmune aspects of type 2 diabetes. These therapies could be focused on reducing the chronic inflammation associated with the disease or modulating the immune cells that contribute to insulin resistance.

How Lifestyle Choices Can Modulate Autoimmune Aspects of Type 2 Diabetes

Lifestyle choices can also play a key role in managing the autoimmune aspects of type 2 diabetes. Research has shown that certain lifestyle choices can help reduce inflammation and improve insulin resistance.

Some proven lifestyle choices that can impact type 2 diabetes outcomes include:

  • Regular exercise
  • A healthy diet low in saturated fat
  • Weight loss (for those who are overweight or obese)
  • Stress reduction techniques like meditation or yoga
  • Quitting smoking

Research has also shown that some of these lifestyle changes can have a direct impact on the immune system. For example, exercise has been shown to reduce inflammation and increase the number of beneficial immune cells in the body.

The Role of Inflammation in Type 2 Diabetes and Autoimmunity

Inflammation is a natural response of the immune system to injuries or infections. However, chronic inflammation can lead to damage in various organs and tissues, contributing to a range of health conditions.

In type 2 diabetes, chronic inflammation is often present and is thought to play a key role in the autoimmune component of the disease. Inflammatory cytokines, molecules produced by the immune system, have been linked to the development of insulin resistance.

Researchers are exploring different ways to target inflammation in type 2 diabetes. Some potential approaches could include using anti-inflammatory medications or modifying lifestyle factors that contribute to inflammation, such as diet and exercise.

Autoimmune Therapies for Type 2 Diabetes: A Promising Future?

While there are currently no FDA-approved autoimmune therapies specifically for type 2 diabetes, there is growing interest in this area of research.

One potential autoimmune therapy that could be adapted for type 2 diabetes is the use of monoclonal antibodies. These antibodies can be designed to specifically target immune cells or proteins that contribute to insulin resistance.

Another promising approach is the use of stem cells to regenerate the insulin-producing cells that are attacked in the autoimmune component of the disease. While this approach is still in its early stages of development, researchers are optimistic about its potential.


While type 2 diabetes has traditionally been classified as a metabolic disorder, recent research has begun to explore potential autoimmune components of the disease. While the scientific community remains divided on whether type 2 diabetes can be entirely classified as an autoimmune disease, there is growing evidence to suggest that aspects of the immune system contribute to its development.

Understanding the potential autoimmune links to type 2 diabetes is important for those affected by the disease. It could help guide new treatment approaches and lead to better outcomes for people with the condition. By making lifestyle changes and exploring potential autoimmune therapies, people living with type 2 diabetes can take control of their health and wellbeing.

Webben Editor

Hello! I'm Webben, your guide to intriguing insights about our diverse world. I strive to share knowledge, ignite curiosity, and promote understanding across various fields. Join me on this enlightening journey as we explore and grow together.

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